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These western medicines mainly involve antibiotics, phosphodiesterase type-5 inhibitor PDE-5iα-blockers. Results: Altogether, 30 pieces of literature with 2, participants containing 11 oral Chinese patent medicine and 11 interventions were included in the NMA. Owing to the limitations of this research, these results should be confirmed by elaborate RCTs.
Sexual dysfunction SD in our studies mainly refer to self-reported erectile dysfunction ED or premature ejaculation PEor both.
However, the effectiveness of α-blockers and antibiotics has been controversial. Therefore, the top priority of treatment is to activate blood circulation and remove dampness. TCM combines syndrome differentiation with disease differentiation was more favorable to us to understand and treat CP. Syndrome differentiation is used to identify different types of a herald zozhe prosztatitis disease to create a specific treatment plan.
It is difficult to decide the superiority of treatment under a meta-analysis of pairwise comparisons. A network meta-analysis NMA combines existing evidence makes it possible to compare different treatment options at the same time. The graphic workflow in our research is illustrated in Figure 1.
Graphic workflow for the NMA. These scores could be divided into three grades: recovery, improvement, and inefficiency.
Ludovit Belavy — student of Medicine. But in the last few days after completing these pages, it all fell in place. There are several forms of prostatitis: acute bacterial prostatitis with complications including prostatic herald zozhe prosztatitis, prostatic infarction death of a part or of the whole prostatechronic prostatitis. Prostatic abscess is a rare complication of acute bacterial prostatitis, that occurs during urinary tract obstruction, diabetes, immunocompromis ed patients and those not adequately treated before. Symptoms are painful swelling of the scrotum, dysuria - painful and difficult urination with or without discharge.
The following studies were excluded: studies involving patients who had 1 major psychological or somatic diseases; 2 the use of drugs that influence sexual function; 3 the use of antibiotics during the preceding 2 weeks; 4 missing or incorrect data; 5 experimental research, retrospective studies, conference abstracts, case reports, and reviews or herald zozhe prosztatitis. The free text words and medical subject herald zozhe prosztatitis MeSH were adopted.
The restriction of language includes English and Chinese. Besides, we manually retrieved the reference of involved researches. After herald zozhe prosztatitis were removed by EndNote X9, two researchers browsed the titles and abstracts of involved researches respectively.
Besides, we also confirmed the potential articles. Any divergence could be solved through discussions or negotiations with a superior researcher. Two authors evaluated the risk of bias.
The intervention was systematically evaluated in randomized controlled trials and Cochrane Handbook.
These western medicines mainly involve antibiotics, phosphodiesterase type-5 inhibitor PDE-5iα-blockers. Results: Altogether, 30 pieces of literature with 2, participants containing 11 oral Chinese patent medicine and 11 interventions were included in the NMA. Owing to the limitations of this research, these results should be confirmed by elaborate RCTs. Sexual dysfunction SD in our studies mainly refer to self-reported erectile dysfunction ED or premature ejaculation PEor both.
Each of these options was evaluated as high, low or unclear. When described a valid generation of random number, blinding, and results, they will be categorized as low-risk, otherwise, they will be high-risk. Once described an ambiguous information, they will be categorized as an unclear a prosztata fájdalom gyulladása. As for statistical processes, Random and fixed effects model was adopted for continuous and dichotomous variables, respectively.
Simulation iterations were commanded toadaptation iterations were required to10, Meanwhile, funnel graphs were plotted to identify the presence of publication bias.
The forest graph, the risk of bias graph, and network plot were also illustrated. The age range of the participants was approximately 15 to 66, and the young and middle-aged crowd made up the majority.
Western medicine regimen contained antibiotics, α-blockers, phosphodiesterase type-5 inhibitor PDE-5ian anti-inflammatory drug, pollen extract, etc. All the eligible Chinese patent medicine were taken orally, and the course of treatment ranged from 3 to 12 weeks, and most of the studies were 8 weeks. The detailed characteristics of herald zozhe prosztatitis researches are demonstrated in Table 1the patented formulations of involved literature are listed in Supplementary Table S1 and the network plots about diverse results could be found in Figure 3.
Characteristics of included studies.
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Quality Assessment Two authors appraised the risk of bias in contained researches respectively by utilizing the Cochrane Risk of Bias Tool proposed by the Cochrane Handbook 5. Items assessed were as follows: Low-risk items: 1 seven herald zozhe prosztatitis about selective bias explained utilized table of random numbers and one study in selection bias stated adopted lottery method.
- Methods Forty-two SD rats were randomly divided into five groupsnormal control groupmodel control groupPushitai group, ursolic acid high- dose group, and low- dose group.
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High-risk events: 1 All studies about selection bias did not adopt allocation concealment. Unclear risk items: 1 22 studies in selection bias did not state specific random method.
A detailed description of the risk of bias evaluation is shown in Figure 4. Risk of bias graph.
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No statistical significance was proved in herald zozhe prosztatitis rest of the treatments. Nevertheless, other interventions had no statistical difference. No statistical significance was testified in the rest of the treatments. No statistical analysis was performed on these secondary outcomes on account of the scarcity of studies and inconsistent evaluation criteria.
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Cluster Analysis The influences of interventions in two diverse results were synthetically contrasted by cluster analysis. The results are shown in Figure 7. Nevertheless, there was no optimum combination associated with a preferable response in both aspects.
Cluster analysis plots.
Interventions located in the upper right corner indicate optimal combination therapy for two different outcomes. Publication Bias A funnel graph for four major outcomes was presented in Figure 8 to evaluate publication bias.
All of the funnel graphs were not completely symmetrical visually, and each of the adjusted auxiliary lines was not perpendicular to the centerline.
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Thus, there may be significant publication bias. Meanwhile, our studies involved utilized treatment based on syndrome differentiation in Herald zozhe prosztatitis Chinese Medicine TCM theories e. Basing on the above theory and method of integrated Chinese and Western medicine, we ranked the outcomes for the sake of offer evidence and recommendations for clinical medication.
Furthermore, from the view of mechanisms, on the one hand, antibiotics could control infection and α-blockers could relaxes smooth muscles in areas such as the prostate and bladder and improves lower urinary tract symptoms and herald zozhe prosztatitis except anxious emotion, on the other hand, traditional Chinese medicine theory believes that anxiety is related to liver stagnation, OCPM could regulate liver stagnation and improves deficiency of kidney and spleen to relieves anxious emotion, improves erectile function and inhibit premature ejaculation ultimately.
Limitations Nevertheless, this research also possessed limitations. In the first place, among 30 literature, only eight literature that utilized the correct method of a random number, none of them adopted allocation concealment, applied the blind method blind to participants and personneland reported blinding of outcome evaluation.
Symptoms disappeared The prostatic glands returned to normal or near normal in the digital rectal examination. In the prostate fluid routine smear the normal cases Hot dissolves cold and stasis blood. As a result, it helps blood circulation and communication of meridians.
The quality of the involved researches herald zozhe prosztatitis not be high, which reduced the persuasiveness of research results. In the second place, limited by application area of OCPM, all researches were reported in China and published in a Chinese journal, lacking the resource in other languages, which is not beneficial to the international promotion of study outcomes.
Prospects Prosztatitis véleménye, we propound the following recommendations: firstly, multicenter randomized double-blind tests should be implemented in rigorous in the light of regulations when conducting RCTs.
The method of a random number, allocation concealment, and blind method performance are committed steps that need to be attentive in the future study program.
Secondly, it is herald zozhe prosztatitis to perform more clinical researches compared to the effect of different OCPM to make up for the absence of study in this domain. But, on account of the limitations of this article, these conclusions were supposed to be certified via multicenter, high-quality, and larger-sample randomized controlled trials.
YZ was responsible for the conduct of the network meta-analysis. YZ and TN saw to the analysis of study information.
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YZ and HM took charge of the writing of the article. ZZ and XG saw to the revision of the article. All authors read and approved the final version of the manuscript. Conflict of Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.